Archives de 22 juillet 2008
Endothelial Cell Migration During Angiogenesis
Publié par Oldcola dans Uncategorized le juillet 22, 2008
Endothelial Cell Migration During Angiogenesis
Laurent Lamalice, Fabrice Le Boeuf, Jacques Huot
Circulation Research. 2007;100:782-794 doi: 10.1161/01.RES.0000259593.07661.1e
Endothelial cell migration is essential to angiogenesis. This motile process is directionally regulated by chemotactic, haptotactic, and mechanotactic stimuli and further involves degradation of the extracellular matrix to enable progression of the migrating cells. It requires the activation of several signaling pathways that converge on cytoskeletal remodeling. Then, it follows a series of events in which the endothelial cells extend, contract, and throw their rear toward the front and progress forward. The aim of this review is to give an integrative view of the signaling mechanisms that govern endothelial cell migration in the context of angiogenesis.
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