Articles tagués Hypoxia

The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens

The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens

Loenarz C, Coleman ML, Boleininger A, Schierwater B, Holland PWH, Ratcliffe PJ, Schofield CJ

EMBO reports (2011) 12, 63 – 70 doi:10.1038/embor.2010.170


hot off the press [pdf link – EMBO reports (2011) 12, 3–4. doi:10.1038/embor.2010.19]

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Experimental selection of hypoxia-tolerant Drosophila melanogaster

Experimental selection of hypoxia-tolerant Drosophila melanogaster.

Zhou D, Udpa N, Gersten M, Visk DW, Bashir A, Xue J, Frazer KA, Posakony JW, Subramaniam S, Bafna V, Haddad GG.

Proc Natl Acad Sci U S A. 2011 Jan 24. [Epub ahead of print] doi: 10.1073/pnas.1010643108

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Role of myocardial hypoxia in the remodeling of the embryonic avian cardiac outflow tract

Role of myocardial hypoxia in the remodeling of the embryonic avian cardiac outflow tract

Yasuyuki Sugishita, Michiko Watanabe, and Steven A. Fisher

Developmental Biology 267 (2004) 294–308 doi:10.1016/j.ydbio.2003.11.017


Capture d’écran 2010-10-09 à 20.58.48.jpgTwo years ago, I pointed to a methodological flaw in one of the papers of Vincent Fleury, which didn’t contain data (or any consideration of) concerning the eventual contribution of hypoxia in one of the experimental settings. That was felt as a lèse majesté crime. The response was rather arrogant and this paper is a nice illustration of what I meant (and mean) about the eventual role of hypoxia. In the work of Sugishita et al. the hypoxic region is embedded in tissue otherwise normoxic. The red label (Cy3) pointed by the arrowheads indicate adducts by EF5, produced preferentially under hypoxic conditions.

So much for Fleury’s comment
This is the case for a normally developing embryo without any artificial occlusion impairing blood’s flow and oxygenation. Just imagine what kind of staining must result from impairing the blood flow!


Now, what are the references for EF5 and the anti-EF5 monoclonals?

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Loss of myeloid cell-derived vascular endothelial growth factor accelerates fibrosis

Loss of myeloid cell-derived vascular endothelial growth factor accelerates fibrosis

Christian Stockmann, Yann Kerdiles, Marc Nomaksteinsky, Alexander Weidemann, Norihiko Takeda, Andrew Doedens, Antonio X. Torres-Collado, Luisa Iruela-Arispe, Victor Nizet, and Randall S. Johnson

PNAS, Published online before print February 8, 2010, doi: 10.1073/pnas.0912766107

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Notch Signal Activates Hypoxia Pathway through HES1-Dependent SRC/Signal Transducers and Activators of Transcription 3 Pathway

Notch Signal Activates Hypoxia Pathway through HES1-Dependent SRC/Signal Transducers and Activators of Transcription 3 Pathway.

Lee JH, Suk J, Park J, Kim SB, Kwak SS, Kim JW, Lee CH, Byun B, Ahn JK, Joe CO.

Mol Cancer Res. 2009 Oct 6. [Epub ahead of print] doi: 10.1158/1541-7786.MCR-09-0191

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Hypoxia and TGF-β Drive Breast Cancer Bone Metastases through Parallel Signaling Pathways in Tumor Cells and the Bone Microenvironment.

Hypoxia and TGF-β Drive Breast Cancer Bone Metastases through Parallel Signaling Pathways in Tumor Cells and the Bone Microenvironment.

Lauren K. Dunn, Khalid S. Mohammad, Pierrick G. J. Fournier, C. Ryan McKenna, Holly W. Davis, Maria Niewolna, Xiang Hong Peng, John M. Chirgwin, Theresa A. Guise

PLoS ONE 4(9): e6896. doi:10.1371/journal.pone.0006896

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Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans

Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans

Ranjana Mehta, Katherine A. Steinkraus, George L. Sutphin, Fresnida J. Ramos, Lara S. Shamieh, Alexander Huh, Christina Davis, Devon Chandler-Brown, Matt Kaeberlein

Science 29 May 2009: Vol. 324. no. 5931, pp. 1196 – 1198 doi: 10.1126/science.1173507

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Activation of hypoxia-inducible factor 1 during macrophage differentiation

Oda, Tomoyuki, Kiichi Hirota, Kenichiro Nishi, Satoshi Takabuchi, Seiko Oda, Hiroko Yamada, Toshiyuki Arai, Kazuhiko Fukuda, Toru Kita, Takehiko Adachi, Gregg L. Semenza, and Ryuji Nohara.

Activation of hypoxia-inducible factor 1 during macrophage differentiation.

Am J Physiol Cell Physiol 291: C104 –C113, 2006. First published February 15, 2006; doi:10.1152/ajpcell.00614.2005.—

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Opposite Effects of Notch-1 and Notch-2 on Mesothelioma Cell Survival under Hypoxia Are Exerted through the Akt Pathway

Opposite Effects of Notch-1 and Notch-2 on Mesothelioma Cell Survival under Hypoxia Are Exerted through the Akt Pathway

Irene Graziani, Sandra Eliasz, Melissa A. De Marco, Yuanbin Chen, Harvey I. Pass, Richard M. De May, Peter R. Strack, Lucio Miele and Maurizio Bocchetta

Cancer Research 68, 9678-9685, December 1, 2008. doi:10.1158/0008-5472.CAN-08-0969

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Red-eyed Treefrog Embryos Actively Avoid Asphyxiation Inside Their Eggs

Red-eyed Treefrog Embryos Actively Avoid Asphyxiation Inside Their Eggs:

Boston University undergraduate Jessica Rogge and associate professor Karen Warkentin, working at the Smithsonian Tropical Research Institute’s laboratories in Gamboa, Panama, discovered that frog embryos at a very early developmental stage actively respond to oxygen levels in the egg—as reported in the Journal of Experimental Biology. These initial responses to the environment may be critical to the frogs’ long-term survival. 

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