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Vertebrate limb bud formation is initiated by localized epithelial-to-mesenchymal transition

Vertebrate limbs first emerge as small buds at specific locations along the trunk. Although a fair amount is known about the molecular regulation of limb initiation and outgrowth, the cellular events underlying these processes have remained less clear. We show that the mesenchymal limb progenitors arise through localized epithelial-to-mesenchymal transition (EMT) of the coelomic epithelium specifically within the presumptive limb fields. This EMT is regulated at least in part by Tbx5 and Fgf10, two genes known to control limb initiation. This work shows that limb buds initiate earlier than previously thought, as a result of localized EMT rather than differential proliferation rates.

Gros J, Tabin CJ.

Science 14 March 2014:  Vol. 343 no. 6176 pp. 1253-1256, doi:10.1126/science.1248228

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A Switch Between Topological Domains Underlies HoxD Genes Collinearity in Mouse Limbs

Guillaume Andrey, Thomas Montavon, Bénédicte Mascrez, Federico Gonzalez, Daan Noordermeer, Marion Leleu, Didier Trono, François Spitz, Denis Duboule

Science 7 June 2013: Vol. 340 no. 6137 dpi: 10.1126/science.1234167

Editors Summary

During limb development, the time and place of Hox transcription are fixed by respective gene position within the gene cluster. Andrey et al. (p. 1234167; see the Perspective by Rodrigues and Tabin) found that this enigmatic property results from the opposite and successive actions of two large regulatory landscapes located on either side of the mouse Hox locus. In the early phase, one of these topological domains regulates transcription in the proximal limb until a switch occurs toward the other topological domain, which takes over the regulation in the distally developing digits. As a side effect of this antagonistic regulatory strategy, cells in-between have lessened Hox transcription, which generates the wrist.

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Gastrulation and pre-gastrulation morphogenesis, inductions, and gene expression: similarities and dissimilarities between urodelean and anuran embryos

Gastrulation and pre-gastrulation morphogenesis, inductions, and gene expression: similarities and dissimilarities between urodelean and anuran embryos

Teruo Kaneda & Jun-ya Doi Motoki

Developmental Biology Available online 25 May 2012 doi :10.1016/j.ydbio.2012.05.019

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The transcription factor Eya2 prevents pressure overload-induced adverse cardiac remodeling

The transcription factor Eya2 prevents pressure overload-induced adverse cardiac remodeling

Seung Hee Lee, Dong Kwon Yang, Bo Youn Choi, Young-Hoon Lee, Seon-Young Kim, Dongtak Jeong, Roger J. Hajjar, Woo Jin Park

Journal of Molecular and Cellular Cardiology, Volume 46, Issue 4, April 2009, Pages 596-605, ISSN 0022-2828, doi: 10.1016/j.yjmcc.2008.12.021

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Cranial Vasculature in Zebrafish Forms By Angioblast Cluster-Derived Angiogenesis

Cranial Vasculature in Zebrafish Forms By Angioblast Cluster-Derived Angiogenesis.

Proulx K, Lu A, Sumanas S.

Dev Biol. 2010 Sep 8 Article in Press, Accepted Manuscript doi:10.1016/j.ydbio.2010.08.036


 

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unchain my heart

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chick embryo development time-lapse

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Cardiovascular Embryology

Cardiovascular Embryology, from SpringerVideos

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Wnt/PCP signaling controls intracellular position of MTOCs during gastrulation convergence and extension movement

Wnt/PCP signaling controls intracellular position of MTOCs during gastrulation convergence and extension movement

Diane S. Sepich, Mohsinah Usmani, Staci Pawlicki and Lila Solnica-Krezel

Development 138, 543-552 (2011) doi:10.1242/dev.05395


Entre les deux y’a pas ‘dintermédiaire. Les gènes ne sont pas en mesure d’arrêter quoi que ce oit, ça tourne dans tous les sens d’une façon démentielle. [Source]


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PDGF-A controls mesoderm cell orientation and radial intercalation during Xenopus gastrulation

PDGF-A controls mesoderm cell orientation and radial intercalation during Xenopus gastrulation

Erich W. Damm and Rudolf Winklbauer

Development 138, 565-575 (2011) doi:10.1242/dev.05690


Entre les deux y’a pas ‘dintermédiaire. Les gènes ne sont pas en mesure d’arrêter quoi que ce oit, ça tourne dans tous les sens d’une façon démentielle. [Source]


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