Articles tagués EMT

Vertebrate limb bud formation is initiated by localized epithelial-to-mesenchymal transition

Vertebrate limbs first emerge as small buds at specific locations along the trunk. Although a fair amount is known about the molecular regulation of limb initiation and outgrowth, the cellular events underlying these processes have remained less clear. We show that the mesenchymal limb progenitors arise through localized epithelial-to-mesenchymal transition (EMT) of the coelomic epithelium specifically within the presumptive limb fields. This EMT is regulated at least in part by Tbx5 and Fgf10, two genes known to control limb initiation. This work shows that limb buds initiate earlier than previously thought, as a result of localized EMT rather than differential proliferation rates.

Gros J, Tabin CJ.

Science 14 March 2014:  Vol. 343 no. 6176 pp. 1253-1256, doi:10.1126/science.1248228

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RhoA and microtubule dynamics control cell–basement membrane interaction in EMT during gastrulation

There is a quite nice paper (full reference and abstract at the end of the post) I would like to present, a little bit more explicitly than usual. Most of the time I’m just dropping over here the references of papers I’m reading during coffee breaks, and sometimes there is a backstage discussion about them (people, comments on blogs are for discussions, please use them at least occasionally instead of e-mail 😉 ).

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Cessation of gastrulation is mediated by suppression of EMT at the VER

Cessation of gastrulation is mediated by suppression of epithelial-mesenchymal transition at the ventral ectodermal ridge

Sho Ohta, Kentaro Suzuki, Katsuro Tachibana, Hideaki Tanaka and Gen Yamada

Development 134, 4315-4324(2007) doi:10.1242/dev.008151

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