A Switch Between Topological Domains Underlies HoxD Genes Collinearity in Mouse Limbs

Guillaume Andrey, Thomas Montavon, Bénédicte Mascrez, Federico Gonzalez, Daan Noordermeer, Marion Leleu, Didier Trono, François Spitz, Denis Duboule

Science 7 June 2013: Vol. 340 no. 6137 dpi: 10.1126/science.1234167

Editors Summary

During limb development, the time and place of Hox transcription are fixed by respective gene position within the gene cluster. Andrey et al. (p. 1234167; see the Perspective by Rodrigues and Tabin) found that this enigmatic property results from the opposite and successive actions of two large regulatory landscapes located on either side of the mouse Hox locus. In the early phase, one of these topological domains regulates transcription in the proximal limb until a switch occurs toward the other topological domain, which takes over the regulation in the distally developing digits. As a side effect of this antagonistic regulatory strategy, cells in-between have lessened Hox transcription, which generates the wrist.

Cranial Vasculature in Zebrafish Forms By Angioblast Cluster-Derived Angiogenesis

Cranial Vasculature in Zebrafish Forms By Angioblast Cluster-Derived Angiogenesis.

Proulx K, Lu A, Sumanas S.

Dev Biol. 2010 Sep 8 Article in Press, Accepted Manuscript doi:10.1016/j.ydbio.2010.08.036

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A ‘chemotactic dipole’ mechanism for large-scale vortex motion during primitive streak formation in the chick embryo

It have been a busy month of august this year and I forgotten the anniversary of the missing L2/R2. Some activity was registered at Brisures d’oeuf for the anniversary, I should have prepare something special for the visitors. Anyway, here is a present for those interested on the subject, with a special mention for Vincent Fleury!
Still two of them 😉

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A ‘chemotactic dipole’ mechanism for large-scale vortex motion during primitive streak formation in the chick embryo

S A Sandersius, M Chuai, C J Weijer and T J Newman

Phys. Biol. 8 (2011) 045008 (11pp) doi:10.1088/1478-3975/8/4/045008

Ptenb Mediates Gastrulation Cell Movements via Cdc42/AKT1 in Zebrafish.

Ptenb Mediates Gastrulation Cell Movements via Cdc42/AKT1 in Zebrafish.

Yeh CM, Liu YC, Chang CJ, Lai SL, Hsiao CD, Lee SJ.

PLoS ONE 6(4): e18702. doi:10.1371/journal.pone.0018702

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Entre les deux y’a pas ‘dintermédiaire. Les gènes ne sont pas en mesure d’arrêter quoi que ce oit, ça tourne dans tous les sens d’une façon démentielle. [Source]

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Protégé : e-mailed

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PDGF-A controls mesoderm cell orientation and radial intercalation during Xenopus gastrulation

PDGF-A controls mesoderm cell orientation and radial intercalation during Xenopus gastrulation

Erich W. Damm and Rudolf Winklbauer

Development 138, 565-575 (2011) doi:10.1242/dev.05690

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Entre les deux y’a pas ‘dintermédiaire. Les gènes ne sont pas en mesure d’arrêter quoi que ce oit, ça tourne dans tous les sens d’une façon démentielle. [Source]

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The Cell Adhesion-associated Protein Git2 Regulates Morphogenetic Movements during Zebrafish Embryonic Development

The Cell Adhesion-associated Protein Git2 Regulates Morphogenetic Movements during Zebrafish Embryonic Development

Jianxin A. Yu, Fiona C. Foley, Jeffrey D. Amack and Christopher E. Turner

Developmental Biology Article in Press, Accepted Manuscript doi: 10.1016/j.ydbio.2010.10.027

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Entre les deux y’a pas ‘dintermédiaire. Les gènes ne sont pas en mesure d’arrêter quoi que ce oit, ça tourne dans tous les sens d’une façon démentielle.

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polydactyly

Via the Carnival of Evolution #29, a post of Bjørn Østman about the six digit cat lead me via the comments (and through Wikipedia; I would go through anything sometimes) to a page by Sarah Hartwell, explaining cats’ polydactyly and it’s genetic determinism.

This is a special post for a great cats observer, who is quite interested on polydactyly and closely observed his cat (as some of you may already know).

Detection of Hypoxic Cells by Monoclonal Antibody Recognizing 2-Nitroimidazole Adducts

Detection of Hypoxic Cells by Monoclonal Antibody Recognizing 2-Nitroimidazole Adducts

Edith M. Lord, Lee Harwell, and Cameron J. Koch

CANCER RESEARCH 53, 5721-5726, December1, 1993

Improved lung growth and function through hypoxia-inducible factor in primate chronic lung disease of prematurity

Improved lung growth and function through hypoxia-inducible factor in primate chronic lung disease of prematurity

Tiina M. Asikainen, Ling-Yi Chang, Jacqueline J. Coalson, Barbara K. Schneider, Nahid S. Waleh, Machiko Ikegami, John M. Shannon, Vicki T. Winter, Peter Grubb, Ronald I. Clyman, Bradley A. Yoder, James D. Crapo, and Carl W. White

The FASEB Journal. 2006;20:1698-1700 doi: 10.1096/fj.06-5887fje