Archives de la catégorie genome

Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution

Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution

Smith JJ, Kuraku S, Holt C, Sauka-Spengler T, Jiang N, Campbell MS, Yandell MD, Manousaki T, Meyer A, Bloom OE, Morgan JR, Buxbaum JD, Sachidanandam R, Sims C, Garruss AS, Cook M, Krumlauf R, Wiedemann LM, Sower SA, Decatur WA, Hall JA, Amemiya CT, Saha NR, Buckley KM, Rast JP, Das S, Hirano M, McCurley N, Guo P, Rohner N, Tabin CJ, Piccinelli P, Elgar G, Ruffier M, Aken BL, Searle SM, Muffato M, Pignatelli M, Herrero J, Jones M, Brown CT, Chung-Davidson YW, Nanlohy KG, Libants SV, Yeh CY, McCauley DW, Langeland JA, Pancer Z, Fritzsch B, de Jong PJ, Zhu B, Fulton LL, Theising B, Flicek P, Bronner ME, Warren WC, Clifton SW, Wilson RK, Li W.

Nat Genet. 2013 Apr;45(4):415-21, 421e1-2. doi: 10.1038/ng.2568. Epub 2013 Feb 24

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Sea lamprey mouth (Photo: T. Lawrence, GLFC)

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Genetic Determinants of Serum Testosterone Concentrations in Men

Genetic Determinants of Serum Testosterone Concentrations in Men

Claes Ohlsson et al.

PLoS Genet 7(10): e1002313. doi:10.1371/journal.pgen.1002313

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Les tests génétiques prédisent-ils notre avenir ?

Science publique, par Michel Alberganti, le 06.05.2011 à 14:00

Avec :

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Mapping copy number variation by population-scale genome sequencing

Mapping copy number variation by population-scale genome sequencing

Ryan E. Mills et al.

Nature 470, 59–65 doi:10.1038/nature09708

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Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation

Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation

Vamsi K Gangaraju, Hang Yin, Molly M Weiner, Jianquan Wang, Xiao A Huang & Haifan Lin

Nature Genetics (2010) doi:10.1038/ng.743


It’s somehow stupid the way this kind of papers are presented in press releases. I grabbed this references from physorg.com, where the heading goes like that:

For decades, biology textbooks have been clear – our traits are the product of our genes. But a new study by Yale University researchers published Dec. 26 in Nature Genetics suggests another mechanism can regulate variations of traits even in genetically identical individuals.

Somewhere in the text is hidden:

Genes do play a role in protecting against harmful variations but probably work through actions of the molecules piRNA and Hsp-90.

Yeah, right, that’s really news! Genes play a role through their encoded products…

If you go and read the whole stuff, and hopefully the paper, you aren’t really overwhelmed by new evidence that genes act through their products, but the paper is excellent: this is an original mechanism of genetic expression regulation and it’s fun to read about it. But, the way it’s presented call for IDiots to read it superficially and draw conclusions that are somehow IDiotic:

It’s getting more and more difficult for those who cling to evolution to escape the facts.

The whole DNA system and now even some extraneous factors are designed to PROTECT against harmful mutations. Just about any random, unspecified mutation is either useless or harmful. There are very few random mutations that are actually good. This is not to be confused with the switching on or off of already existing genes which would in most cases be the source for speciation.

Tiring, isn’t it?

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2R and remodeling of vertebrate signal transduction engine

2R and remodeling of vertebrate signal transduction engine

Lukasz Huminiecki and Carl H Heldi
BMC Biology 2010, 8:146 doi:10.1186/1741-7007-8-14 Lire la suite »

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Genome merger: from sequence rearrangements in triticale to their elimination in wheat–rye addition lines

Genome merger: from sequence rearrangements in triticale to their elimination in wheat–rye addition lines

Miguel Bento, Perry Gustafson , Wanda Viegas and Manuela Silva

Theoretical and Applied Genetics, Volume 121, Number 3 / août 2010, doi: 10.1007/s00122-010-1325-6

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the beginning

Dans mon e-mail, petite dédicace à @SamiaHurst :

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Epigenetics as a unifying principle in the aetiology of complex traits and diseases

Epigenetics as a unifying principle in theaetiology of complex traits and diseases

Arturas Petronis

Nature 465, 721–727 (10 June 2010) doi:10.1038/nature09230

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400andme

Les commentaires chez S. Huet sont fermés ! Je les active donc ici.

Je signalais il y a quelques jours un billet de Sylvestre Huet mettant en avant le texte de mise en garde contre les tests génétiques et surtout leur interprétation, signé par une dizaine de sociétés savantes, dont l’objet est relatif à la génétique.

Il y a eu une amorce de discussion dans les commentaires, dont l’un des intervenants, JLS, est un des signataires du texte en question; il indique 400 signataires, d’où mon titre. Il est heureux de voir que des scientifiques prennent le temps d’attirer l’attention du public sur les problèmes que peuvent receler certains produits commerciaux. On ne peut qu’espérer que cette attitude inspirera à d’autres sociétés savantes le besoin de prendre le temps nécessaire pour attirer l’attention sur d’autres types de produits et services qui sont disponibles sur le marché et qui pourraient présenter des risques bien plus importants que ce que les généticiens dénoncent ici.

Revenons au texte présenté par SFGH, FFGH, ACLF, ANPGM, AFGCCG, AFCG, SOFFOET, CPEGM, SFG, ADELF : QUELLE VALEUR ACCORDER AUX PREDICTIONS DE RISQUES POUR LES MALADIES MULTIFACTORIELLES ?

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