A tissue-engineered jellyfish with biomimetic propulsion

A tissue-engineered jellyfish with biomimetic propulsion

Janna C Nawroth, Hyungsuk Lee, Adam W Feinberg, Crystal M Ripplinger, Megan L McCain, Anna Grosberg, John O Dabiri & Kevin Kit Parker

Nature Biotechnology (2012) doi:10.1038/nbt.2269

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Reverse engineering of biological form and function requires hierarchical design over several orders of space and time. Recent advances in the mechanistic understanding of biosynthetic compound materials, computer-aided design approaches in molecular synthetic biology and traditional soft robotics and increasing aptitude in generating structural and chemical microenvironments that promote cellular self-organization have enhanced the ability to recapitulate such hierarchical architecture in engineered biological systems. Here we combined these capabilities in a systematic design strategy to reverse engineer a muscular pump. We report the construction of a freely swimming jellyfish from chemically dissociated rat tissue and silicone polymer as a proof of concept. The constructs, termed ‘medusoids’, were designed with computer simulations and experiments to match key determinants of jellyfish propulsion and feeding performance by quantitatively mimicking structural design, stroke kinematics and animal-fluid interactions. The combination of the engineering design algorithm with quantitative benchmarks of physiological performance suggests that our strategy is broadly applicable to reverse engineering of muscular organs or simple life forms that pump to survive.

  1. #1 par Silas le juillet 23, 2012 - 5:51

    Just a little note. Reverse engineering presumes engineering.

  2. #2 par Oldcola le juillet 23, 2012 - 6:07

    nope! the strict definition presumes the analysis of an artifact:

    Reverse engineering is the process of discovering the technological principles of a device, object, or system through analysis of its structure, function, and operation.

    but one can extend it to non artifactual objects and systems
    [edit]: may I suggest Systems biology: Reverse engineering the cell

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