VEGF and ephrin-B2: a bloody duo
Stéphane Germain & Anne Eichmann
Nature Medicine 16, 752–754 (2010) doi:10.1038/nm0710-752
Ephrin-B2 is required for the formation of blood and lymphatic vessels, but the mechanism has been enigmatic. Two independent studies show that ephrin-B2 controls the internalization and signaling of two types of vascular endothelial growth factor (VEGF) receptors—thereby regulating VEGF-induced angiogenesis in normal and pathological conditions.