Combination MMRV vaccine linked with 2-fold risk of seizures

Electronic health records study of 459,000 children sparked new CDC recommendations
Oakland, CA (June 28) – The combination vaccine for measles, mumps, rubella and chickenpox (MMRV) is associated with double the risk of febrile seizures for 1- to 2-year-old children compared with same-day administration of the separate vaccine for MMR (measles, mumps, rubella) and the varicella (V) vaccine for chicken pox, according to a Kaiser Permanente Division of Research study appearing online in the journal Pediatrics. A febrile seizure is a brief, fever-related convulsion but it does not lead to epilepsy or seizure disorders, researchers explained.

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  1. #1 par kmwindisch le juin 28, 2010 - 6:58

    this is a well described phenomenon. while these seizures aren’t dangerous they are very frightening. this comp-lication can be eliminated by using separate varicella and MMR vaccines (given on the same day, just not in the same syringe.) Mixing the two drugs into one, called proquad) requires higher than normal doses of varicella due to some pH issues affecting immunogenicity and subsequently this increases the rate of complications.

    Kevin M. Windisch MD, FAAP

  2. #2 par Oldcola le juin 28, 2010 - 7:06

    Thank you for the precisions Kevin, I didn’t knew about that pH/dose issue. Will have to find something to read about it now, any suggestions ?

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