Multiple sclerosis and lung cancer: an unexpected inverse association
A.E. Handel, A. Joseph and S.V. Ramagopalan
QJM Advance Access published online on May 20, 2010 doi:10.1093/qjmed/hcq071
And how about a multiple sclerosis model that predict the inverse association? 😀
Multiple sclerosis is associated with a decreased risk of cancer. Smoking is a risk factor both for multiple sclerosis and lung cancer. We performed a meta-analysis on studies of cancer frequency in multiple sclerosis.
Surprisingly, we found that the risk of lung cancer is reduced in multiple sclerosis [odds ratio 0.67 (95% confidence interval 0.59–0.76) P < 0.00001]. Since this does not appear to be secondary to altered smoking behaviour, we hypothesise that this may be secondary to altered immune surveillance.