Archives de 2 mai 2008

Michael Behe expelled?

Not from academia, from Ben Stein’s movie!

Brian Switek talks about that at Laelaps. I had some difficulties to see the video from YouTube, reachning the « This video is not available in your country. » message!
Well, never mind, it’s available here 😛

And this is the frame:

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Publicités

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ScienceDaily Picks

Selfishness May Be Altruism’s Unexpected Ally: (May 2, 2008 ) — Just as religions dwell upon the eternal battle between good and evil, angels and devils, evolutionary theorists dwell upon the eternal battle between altruistic and selfish behaviors in the Darwinian struggle for existence. In a new study published in the Proceedings of the National Academy of Sciences (PNAS), evolutionary theorists at Binghamton University suggest that selfishness might not be such a villain after all.


Prozac May Help Curb Disease Activity In Multiple Sclerosis: (May 2, 2008 ) — The antidepressant Prozac may help to curb disease activity in the relapsing remitting form of multiple sclerosis (MS), reveals preliminary research published ahead of print in the Journal of Neurology Neurosurgery and Psychiatry.


Diabetes Link To Alzheimer’s Disease Explained: (May 2, 2008 ) — Diabetic individuals have a significantly higher risk of developing Alzheimer’s disease but the molecular connection between the two remains unexplained. Now, researchers at the Salk Institute for Biological Studies identified the probable molecular basis for the diabetes — Alzheimer’s interaction.


Eight New Human Genome Projects Offer Large-scale Picture Of Genetic Difference: (May 2, 2008 ) — A nationwide consortium led by the University of Washington in Seattle has completed the first sequence-based map of structural variations in the human genome, giving scientists an overall picture of the large-scale differences in DNA between individuals. The project gives researchers a guide for further research into these structural differences, which are believed to play an important role in human health and disease. The results appear in the May 1 issue of the journal Nature.


Stem Cell Researchers Create Heart And Blood Cells From Reprogrammed Skin Cells: (May 1, 2008 ) — Stem cell researchers at UCLA were able to grow functioning cardiac cells using mouse skin cells that had been reprogrammed into cells with the same unlimited properties as embryonic stem cells.

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Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway

Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway
Marco J Koudijs, Marjo J den Broeder, Evelyn Groot and Fredericus JM van Eeden
BMC Developmental Biology 2008, 8:15doi:10.1186/1471-213X-8-15

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Background
Aberrant activation of the Hedgehog (Hh) signaling pathway in different organisms has shown the importance of this family of morphogens during development. Genetic screens in zebrafish have assigned specific roles for Hh in proliferation, differentiation and patterning, but mainly as a result of a loss of its activity. We attempted to fully activate the Hh pathway by removing both receptors for the Hh proteins, called Patched1 and 2, which are functioning as negative regulators in this pathway.

Results
Here we describe a splice-donor mutation in Ptc1, called ptc1hu1602, which in a homozygous state results in a subtle eye and somite phenotype. Since we recently positionally cloned a ptc2 mutant, a ptc1;ptc2 double mutant was generated, showing severely increased levels of ptc1, gli1 and nkx2.2a, confirming an aberrant activation of Hh signaling. As a consequence, a number of phenotypes were observed that have not been reported previously using Shh mRNA overexpression. Somites of ptc1;ptc2 double mutants do not express anteroposterior polarity markers, however initial segmentation of the somites itself is not affected. This is the first evidence that segmentation and anterior/posterior (A/P) patterning of the somites are genetically uncoupled processes. Furthermore, a novel negative function of Hh signaling is observed in the induction of the fin field, acting well before any of the previously reported function of Shh in fin formation and in a way that is different from the proposed early role of Gli3 in limb/fin bud patterning.

Conclusion
The generation and characterization of the ptc1;ptc2 double mutant assigned novel and unexpected functions to the Hh signaling pathway. Additionally, these mutants will provide a useful system to further investigate the consequences of constitutively activated Hh signaling during vertebrate development.

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