Notch-1 signalling is activated in brain arteriovenous malformations in humans

Notch-1 signalling is activated in brain arteriovenous malformations in humans.
Zhuge Q, Zhong M, Zheng W, Yang GY, Mao X, Xie L, Chen G, Chen Y, Lawton MT, Young WL, Greenberg DA, Jin K.
Brain Advance Access published online on October 7, 2009, doi:10.1093/brain/awp246

Lire l'intégralité de l'article »

Notch Signal Activates Hypoxia Pathway through HES1-Dependent SRC/Signal Transducers and Activators of Transcription 3 Pathway

Notch Signal Activates Hypoxia Pathway through HES1-Dependent SRC/Signal Transducers and Activators of Transcription 3 Pathway.
Lee JH, Suk J, Park J, Kim SB, Kwak SS, Kim JW, Lee CH, Byun B, Ahn JK, Joe CO.
Mol Cancer Res. 2009 Oct 6. [Epub ahead of print] doi: 10.1158/1541-7786.MCR-09-0191

Lire l'intégralité de l'article »

Shear Stress Increases Expression of the Arterial Endothelial Marker EphrinB2 in Murine ES Cells via the VEGF-Notch Signaling Pathways

Shear Stress Increases Expression of the Arterial Endothelial Marker EphrinB2 in Murine ES Cells via the VEGF-Notch Signaling Pathways
Tomomi Masumura, Kimiko Yamamoto, Nobutaka Shimizu, Syotaro Obi, Joji Ando
Arterioscler Thromb Vasc Biol, doi: 10.1161/ATVBAHA.109.193185

Lire l'intégralité de l'article »

The metalloprotease ADAM10 is required for notch1 S2 cleavage

The metalloprotease ADAM10 is required for notch1 S2 cleavage.
van Tetering G, van Diest P, Verlaan I, van der Wall E, Kopan R, Vooijs M.
JBC Papers in Press published on September 2, 2009 as doi:10.1074/jbc.M109.006775

Lire l'intégralité de l'article »

Notch signalling and haematopoietic stem cell formation during embryogenesis

Notch signalling and haematopoietic stem cell formation during embryogenesis.
Gering M, Patient R.
Journal of Cellular Physiology, Published Online: 1 Sep 2009, doi: 10.1002/jcp.21905

Lire l'intégralité de l'article »

Notch pathway regulation of chondrocyte differentiation and proliferation during appendicular and axial skeleton development

Notch pathway regulation of chondrocyte differentiation and proliferation during appendicular and axial skeleton development
Timothy J. Mead and Katherine E. Yutzey
PNAS 2009 106:14420-14425, doi:10.1073/pnas.0902306106

Lire l'intégralité de l'article »

DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency

DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency.
Hoey T, Yen WC, Axelrod F, Basi J, Donigian L, Dylla S, Fitch-Bruhns M, Lazetic S, Park IK, Sato A, Satyal S, Wang X, Clarke MF, Lewicki J, Gurney A.
Cell Stem Cell. 2009 Aug 7;5(2):168-77
And Comment:
Molecular targeting of cancer stem cells.Gupta R, Vyas P, Enver T.
Cancer [...]

Lire l'intégralité de l'article »

Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice

Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice
Hong Chen, Genevieve Ko, Alessandra Zatti, Giuseppina Di Giacomo, Lijuan Liu, Elisabetta Raiteri, Ezio Perucco, Chiara Collesi, Wang Min, Caroline Zeiss, Pietro De [...]

Lire l'intégralité de l'article »

Pleiotrophin regulates lung epithelial cell proliferation and differentiation during fetal lung development via ß-catenin and Dlk1.

Pleiotrophin regulates lung epithelial cell proliferation and differentiation during fetal lung development via ß-catenin and Dlk1.
Weng T, Gao L, Bhaskaran M, Guo Y, Gou D, Narayanaperumal J, Chintagari NR, Zhang K, Liu L.
JBC Papers in Press published on August 6, 2009 as doi:10.1074/jbc.M109.052530

Lire l'intégralité de l'article »

The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis

The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis.
Benedito R, Roca C, Sörensen I, Adams S, Gossler A, Fruttiger M, Adams RH.
Cell. 2009 Jun 12;137(6):1124-35. doi:10.1016/j.cell.2009.03.025

Lire l'intégralité de l'article »