Uncoupling heart cell specification and migration in the simple chordate Ciona intestinalis

Uncoupling heart cell specification and migration in the simple chordate Ciona intestinalis

Brad Davidson, Weiyang Shi and Michael Levine

Development 132, 4811-4818. doi: 10.1242/dev.02051

Wnt/PCP signaling controls intracellular position of MTOCs during gastrulation convergence and extension movement

Wnt/PCP signaling controls intracellular position of MTOCs during gastrulation convergence and extension movement

Diane S. Sepich, Mohsinah Usmani, Staci Pawlicki and Lila Solnica-Krezel

Development 138, 543-552 (2011) doi:10.1242/dev.05395

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Entre les deux y’a pas ‘dintermédiaire. Les gènes ne sont pas en mesure d’arrêter quoi que ce oit, ça tourne dans tous les sens d’une façon démentielle. [Source]

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A Cell-based Model of Endothelial Cell Migration, Proliferation and Maturation During Corneal Angiogenesis

A Cell-based Model of Endothelial Cell Migration, Proliferation and Maturation During Corneal Angiogenesis

Trachette Jackson and Xiaoming Zheng

Bulletin of Mathematical Biology doi: 10.1007/s11538-009-9471-1

An essential role for Rac1 in endothelial cell function and vascular development

An essential role for Rac1 in endothelial cell function and vascular development

Wenfu Tan, Todd R. Palmby, Julie Gavard, Panomwat Amornphimoltham, Yi Zheng and J. Silvio Gutkind

The FASEB Journal. 2008;22:1829-1838, doi: 10.1096/fj.07-096438

Endothelial Cell Migration During Angiogenesis

Endothelial Cell Migration During Angiogenesis

Laurent Lamalice, Fabrice Le Boeuf, Jacques Huot

Circulation Research. 2007;100:782-794 doi: 10.1161/01.RES.0000259593.07661.1e

Endothelial cell migration is essential to angiogenesis. This motile process is directionally regulated by chemotactic, haptotactic, and mechanotactic stimuli and further involves degradation of the extracellular matrix to enable progression of the migrating cells. It requires the activation of several signaling pathways that converge on cytoskeletal remodeling. Then, it follows a series of events in which the endothelial cells extend, contract, and throw their rear toward the front and progress forward. The aim of this review is to give an integrative view of the signaling mechanisms that govern endothelial cell migration in the context of angiogenesis.