Posted in development, genetics, modelisation, taggé twt, unlit fervency on mai 8, 2008 | Aucun commentaire »
Nature , | doi:10.1038/nature07005
The branching programme of mouse lung development
Ross J. Metzger, Ophir D. Klein, Gail R. Martin & Mark A. Krasnow
Il n’y a pas longtemps je discutais de la bonne modélisation, enfin, bonne dans le sens ou je l’aime. Et je l’aime basée sur des données, réaliste.
Un nouvel exemple ici avec [...]
Posted in evolution, genetics, taggé byog, cyanophage, virus on avril 7, 2008 | Aucun commentaire »
by Merry
Of necessity, viruses rely on their host cells for both energy and molecular building blocks. Typically, lytic infection shuts down the synthesis of host proteins, and the cell’s translation machinery is put to work in the service of viral replication. For marine cyanophage, this strategy runs into a troublesome wrinkle. [Continue reading]
Posted in genetics, taggé Chordates, Skeletogenesis, twt on avril 6, 2008 | Aucun commentaire »
Evolution of a Core Gene Network for Skeletogenesis in Chordates: ”
by Jochen Hecht, Sigmar Stricker, Ulrike Wiecha, Asita Stiege, Georgia Panopoulou, Lars Podsiadlowski, Albert J. Poustka, Christoph Dieterich, Siegfried Ehrich, Julia Suvorova, Stefan Mundlos, Volkhard Seitz
Author Summary
Important molecular mechanisms underlying mammalian skeletogenesis have been described but knowledge about the evolutionary origin of these gene networks [...]
Posted in evolution, genetics on avril 6, 2008 | Aucun commentaire »
Role of Duplicate Genes in Robustness against Deleterious Human Mutations: ”
by Tzu-Lin Hsiao, Dennis Vitkup
Author Summary
Genetic robustness is the ability of an organism to buffer deleterious genetic mutations. It has been previously demonstrated that the functional compensation by duplicates plays an important role in protection against gene deletions in model organisms. Close duplicates often share [...]
Posted in genetics, taggé epistasis, systems biology on avril 6, 2008 | Aucun commentaire »
From Classical Genetics to Quantitative Genetics to Systems Biology: Modeling Epistasis: ”
by David L. Aylor, Zhao-Bang Zeng
Author Summary
Epistasis has long had two slightly different meanings depending on the context in which it is discussed. The classical definition describes an allele at one locus completely masking the effect of an allele at a second locus. Such [...]
Posted in discussions, genetics, memetics, notes on mars 15, 2008 | 1 Commentaire »
J’ai eu une micro-discussion hier avec deux p’tites collègues, qui a commencé avec la mention de la biologie synthétique à la Venter, dérivé vers le déterminisme génétique et interrompue par l’arrivée du tram que je ne devais pas louper. J’ai profité de l’intermède du WE pour leur trouver deux références à lire avant de continuer [...]
