Posted in bioinformatics, development, genome, taggé twt on avril 24, 2008 | 4 Commentaires »
Leroy Hood a le beau rôle du défenseur de la biologie des systèmes qui présente un bijou du domaine, le travail de Oliveri, Tu et Davidson, publié dans le même numéro des PNAS (Global regulatory logic for specification of an embryonic cell lineage)
C’est Timothée qui a attiré mon attention sur les deux papiers, et je [...]
Posted in bioinformatics, simulation, taggé artificial life, homeostasis on avril 6, 2008 | Aucun commentaire »
The Evolution of Robust Development and Homeostasis in Artificial Organisms: ”
by David Basanta, Mark Miodownik, Buzz Baum
Author Summary
During development, multicellular animals are shaped by cell proliferation, cell rearrangement, and cell death to generate an adult whose form is maintained over time. Disruption of this finely balanced state can have devastating consequences, including aging, psoriasis, and [...]
Posted in bioinformatics, taggé 2966, macrophage, TLRs on avril 6, 2008 | Aucun commentaire »
Uncovering a Macrophage Transcriptional Program by Integrating Evidence from Motif Scanning and Expression Dynamics: ”
by Stephen A. Ramsey, Sandy L. Klemm, Daniel E. Zak, Kathleen A. Kennedy, Vesteinn Thorsson, Bin Li, Mark Gilchrist, Elizabeth S. Gold, Carrie D. Johnson, Vladimir Litvak, Garnet Navarro, Jared C. Roach, Carrie M. Rosenberger, Alistair G. Rust, Natalya Yudkovsky, Alan [...]
Posted in PLoS ONE, bioinformatics, multiple sclerosis, taggé , gene network, IFN-ß, JAG1, Jagged1, PBMC, T-cell activation, Th1, Th2, Treg on novembre 27, 2007 | Aucun commentaire »
Palacios R, Goni J, Martinez-Forero I, Iranzo J, Sepulcre J (2007) A Network Analysis of the Human T-Cell Activation Gene Network Identifies Jagged1 as a Therapeutic Target for Autoimmune Diseases.
PLoS ONE 2(11): e1222. doi:10.1371/journal.pone.0001222
Posted in bioinformatics, development, taggé development, genepaint, HTP, ISH, Pax6, regulatory pathway on octobre 22, 2007 | Aucun commentaire »
Visel A, Carson J, Oldekamp J, Warnecke M, Jakubcakova V, et al. (2007) Regulatory Pathway Analysis by High-Throughput In Situ Hybridization. PLoS Genet 3(10): e178 doi:10.1371/journal.pgen.0030178
I suspected that some simpler then the mouse model organism would be used for such systematic approaches, and Ciona intestinalis was one of my candidates, along with chick. Well, mouse [...]
Posted in bioinformatics, evolution, modelisation, simulation on octobre 16, 2007 | 1 Commentaire »
By Silly Designer’s suggestion I came to read this paper dealing with Cairn’s related problematics.
It’s nice to have a few models available explaining the results obtained, but it would be much nicer to get some bench results taking in account the partial polyploidy due to incomplete divisions that could explain a lot of [...]
Posted in bioinformatics, genome on octobre 12, 2007 | Aucun commentaire »
SAN DIEGO (GenomeWeb News) — The J. Craig Venter Institute plans to launch a large-scale human genome sequencing study that aims to map approximately 10,000 genomes within the next decade, a JCVI scientist said this week.
Great news for human genome DNA sequence data junkies. That will be great to have such an amount of data [...]
Posted in bioinformatics on octobre 2, 2007 | Aucun commentaire »
Bio::Blogs #15 en ligne depuis hier, et j’ai failli l’oublier. Trop d’émotions ces deux derniers jours Sans hésitation aucune, mon coup de coeur Bridging the gap between social tagging and semantic annotation: E.D. the Entity Describer, Benjamin Good, Edward Kawas, & Mark Wilkinson
