Angiogenesis but not neurogenesis is critical for normal learning and memory acquisition

Angiogenesis but not neurogenesis is critical for normal learning and memory acquisition

Kerr AL, Steuer EL, Pochtarev V, Swain RA.

Neuroscience Article in Press, Accepted Manuscript doi:10.1016/j.neuroscience.2010.08.008

I’m obsessed with angiogenesis and this have to do with my current work. I came to think that EC play a central role in CNS physiology, especially repair. EC lead you to angiogenesis – invariably.
I love this paper and I’m looking forward to read the discussions it could should must trigger.


Aerobic exercise has been well established to promote enhanced learning and memory in both human and non-human animals. Exercise regimens enhance blood perfusion, neo-vascularization, and neurogenesis in nervous system structures associated with learning and memory. The impact of specific plastic changes to learning and memory performance in exercising animals are not well understood. The current experiment was designed to investigate the contributions of angiogenesis and neurogenesis to learning and memory performance by pharmacologically blocking each process in separate groups of exercising animals prior to visual spatial memory assessment. Results from our experiment indicate that angiogenesis is an important component of learning as animals receiving an angiogenesis inhibitor exhibit retarded Morris water maze (MWM) acquisition. Interestingly, our results also revealed that neurogenesis inhibition improves learning and memory performance in the MWM. Animals that received the neurogenesis inhibitor displayed the best overall MWM performance. These results point to the importance of vascular plasticity in learning and memory function and provide empirical evidence to support the use of manipulations that enhance vascular plasticity to improve cognitive function and protect against natural cognitive decline.

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  1. #1 par Enrike G. Argandoña le octobre 28, 2010 - 12:01

    Hi, If you are interested in angiogenesis and brain, maybe you could have a look to our work:

    http://www.ehu.es/ehusfera/lance/tag/relevant-publications/

    Have a nice day

  2. #2 par Oldcola le octobre 28, 2010 - 1:41

    Hi Enrike,
    Thank you for the link, I’ll check it ASAP. Your name figures between the authors of one paper I can’t get through the usual channels of the university, a pdf would be welcome

  3. #3 par Oldcola le octobre 28, 2010 - 1:49

    Never mind my previous comment, I got the missing paper from your repository :-) Nice!

  4. #4 par Enrike G. Argandoña le octobre 28, 2010 - 3:55

    It has been a pleasure. If you have any comment, question or reuqest, please be free to answer.

  5. #5 par thierry le octobre 29, 2010 - 9:37

    « Aerobic exercise has been well established to promote enhanced learning and memory in both human and non-human animals. »

    Désormais, je prendrai toujours un livre quand j’irai courir. Merci la science : )

  6. #6 par Oldcola le octobre 29, 2010 - 9:42

    Thierry, il faut essayer en lisant le journal, ça c’est du fun mec !

  7. #7 par thierry le octobre 29, 2010 - 9:53

    Comme quoi, on s’est complétement gouré. Les neurones, ça sert à rien. C’est des vaisseaux sanguins qu’il faut pour penser.

    Sinon, pour le journal, j’essaie demain :)

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